症例 challenge · Hematology / Emergency / Critical care · teaching

Thrombotic Thrombocytopenic Purpura (TTP) — Pathway · case challenge

Given a case, work through the care pathway step by step; the tool checks each choice and scores you. Decisions and basis are taken from this site's reviewed care pathways.

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Case #1Hematology / Emergency / Critical care

📋 Case data

PLASMIC / clinical probabilityLow probability

Data is taken from this pathway's reviewed node text. Work through the pathway step by step.

Step 1 / 1 · PLASMIC / clinical probability

PLASMIC score / high clinical suspicion of TTP?

💡 Microangiopathic hemolytic anemia (MAHA) + thrombocytopenia with no other cause → suspect TTP (ADAMTS13 <10%). The pentad (+ neuro/renal/fever) is present in only ~10%. Labs: schistocytes, raised LDH, low haptoglobin, raised indirect bilirubin, normal PT/APTT (distinguishes from DIC), negative Coombs. PLASMIC score (platelets <30, hemolysis, no active cancer/transplant, MCV <90, INR <1.5, Cr <2.0) 6–7 = high risk.

For teaching. Decisions and their basis are taken from this site's reviewed care pathways; for licensed clinicians/trainees, this does not replace clinical judgment or local protocols.