症例 challenge · Hematology-oncology / Emergency / Nephrology · teaching

Tumor Lysis Syndrome (TLS) — Management Pathway · case challenge

Given a case, work through the care pathway step by step; the tool checks each choice and scores you. Decisions and basis are taken from this site's reviewed care pathways.

← View the full flowchartBased on Cairo-Bishop

Case #1Hematology-oncology / Emergency / Nephrology

📋 Case data

Cairo-Bishop classificationHigh-risk only, not yet TLS

Data is taken from this pathway's reviewed node text. Work through the pathway step by step.

Step 1 / 1 · Cairo-Bishop classification

Cairo-Bishop classification (laboratory/clinical TLS or high-risk)?

💡 Most common after chemotherapy of high-burden hematologic malignancies (day 3 before to day 7 after). Laboratory TLS = ≥2 abnormalities or a 25% change from baseline: uric acid ≥476 µmol/L (8 mg/dL), potassium ≥6.0 mmol/L, phosphate ≥1.45 mmol/L (adults), calcium ≤1.75 mmol/L. Clinical TLS = laboratory TLS + one of: creatinine ≥1.5× ULN (AKI), arrhythmia/sudden death, seizure.

For teaching. Decisions and their basis are taken from this site's reviewed care pathways; for licensed clinicians/trainees, this does not replace clinical judgment or local protocols.