🫘 Urine Protein/Creatinine Ratio for 24h Proteinuria

When to use

Enter urine protein and urine creatinine (both mg/dL); the tool returns the estimated daily proteinuria and a category band.

How it works

Estimated 24h proteinuria (g) ≈ urine protein (mg/dL) / urine creatinine (mg/dL). Bands: <0.15 normal, 0.15–0.5 mild, 0.5–3 moderate, ≥3.5 nephrotic.

Key points

• A first-morning specimen is preferred, as orthostatic and exercise-related proteinuria inflate random samples (original synthesis · not guideline verbatim).
• Results are distorted by abnormal muscle mass and extreme urine concentration, where creatinine excretion deviates from the ~1 g/day assumption.
• If urine creatinine is reported in mmol/L, convert (×11.3 to mg/dL) before applying the ratio.

References

• Ginsberg JM, et al. Use of single voided urine samples to estimate quantitative proteinuria. N Engl J Med. 1983.
• KDIGO 2012 Clinical Practice Guideline for the Evaluation and Management of CKD. Kidney Int Suppl. 2013.

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