🫘 Creatinine Clearance (Cockcroft-Gault)
Estimate creatinine clearance with the Cockcroft-Gault equation for renal drug dosing.
Clinical takeaway
Still referenced by many drug labels for dosing.
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When to use
Renal dose adjustment where labels reference creatinine clearance.
How it works
CrCl = (140 − age) × weight × (0.85 if female) / (72 × SCr). SCr in mg/dL.
Key points
- Still referenced by many drug labels for dosing.
- Choose actual, ideal or adjusted weight per drug guidance.
- Not BSA-normalised — use CKD-EPI for CKD staging.
References
Decision support for licensed clinicians only; not a substitute for clinical judgement, diagnosis or local protocols.
Worked calculation
The values below come from this tool's own example placeholders and are computed server-side with the formula shown on this page, so the arithmetic can be checked quickly. It demonstrates how to substitute values only — it is not clinical advice and not a real case.
| Age | 60 years |
|---|---|
| Weight | 70 kg |
| Serum creatinine | 1.0 mg/dL |
| Sex | Male |
→CrCl78mL/min
- Formula：(140−age)·weight·(0.85 if female) / (72·SCr)
- Note：Use actual body weight if not obese; consider ideal/adjusted weight in obesity.
| Age | 60 years |
|---|---|
| Weight | 70 kg |
| Serum creatinine | 1.0 mg/dL |
| Sex | Female |
→CrCl66mL/min
- Formula：(140−age)·weight·(0.85 if female) / (72·SCr)
- Note：Use actual body weight if not obese; consider ideal/adjusted weight in obesity.
Frequently asked questions
- What is Creatinine Clearance (Cockcroft-Gault)?
- Estimate creatinine clearance with the Cockcroft-Gault equation for renal drug dosing.
- How is Creatinine Clearance (Cockcroft-Gault) calculated? What is the core formula?
- CrCl = (140 − age) × weight × (0.85 if female) / (72 × SCr). SCr in mg/dL.
- When is Creatinine Clearance (Cockcroft-Gault) used?
- Renal dose adjustment where labels reference creatinine clearance.
- What are the key clinical points for Creatinine Clearance (Cockcroft-Gault)?
- Still referenced by many drug labels for dosing. Choose actual, ideal or adjusted weight per drug guidance. Not BSA-normalised — use CKD-EPI for CKD staging.
- What are the limits and cautions when using Creatinine Clearance (Cockcroft-Gault)?
- For licensed clinicians and clinical researchers. Interpret results with history, investigations and local protocols; not a diagnosis or prescription, and not a substitute for multidisciplinary decision-making or local guidelines.
- How is Creatinine Clearance (Cockcroft-Gault) calculated in practice? Can you show a worked example?
- Inputs: Age 60 years, Weight 70 kg, Serum creatinine 1.0 mg/dL, Sex Male → Result: CrCl 78 mL/min（Formula: (140−age)·weight·(0.85 if female) / (72·SCr), Note: Use actual body weight if not obese; consider ideal/adjusted weight in obesity.） Inputs: Age 60 years, Weight 70 kg, Serum creatinine 1.0 mg/dL, Sex Female → Result: CrCl 66 mL/min（Formula: (140−age)·weight·(0.85 if female) / (72·SCr), Note: Use actual body weight if not obese; consider ideal/adjusted weight in obesity.）