🎗️ Sedlis Criteria (Adjuvant RT after Cervical Cancer Surgery)
After radical surgery for early cervical cancer (nodes/margins/parametria negative), check the Sedlis intermediate-risk criteria from LVSI, stromal invasion depth and tumour size to decide adjuvant pelvic radiation. Instant, browser-side.
Sedlis Criteria (Adjuvant RT after Cervical Cancer Surgery)
Lymphovascular space invasion (LVSI)
Cervical stromal invasion depth
Maximum tumour diameter (cm)
When to use
Decide adjuvant pelvic radiation for the intermediate-risk group after radical hysterectomy for early cervical cancer.
How it works
Meets if any: LVSI+ & deep 1/3 (any size); LVSI+ & mid 1/3 & ≥ 2 cm; LVSI+ & superficial 1/3 & ≥ 5 cm; LVSI− & mid/deep 1/3 & ≥ 4 cm.
Key points
- The Sedlis criteria apply only when nodes, margins and parametria are negative; positive findings are high-risk (Peters) and get chemoradiation.
- Meeting the criteria supports adjuvant pelvic external-beam radiation — GOG-92 showed roughly a 46% reduction in recurrence.
- Whether to add concurrent platinum chemotherapy for intermediate risk is individualised and varies by centre.
- NCCN notes risk factors are not strictly limited to the original Sedlis combinations.
References
Decision support for licensed clinicians only; not a substitute for clinical judgement, diagnosis or local protocols.