🎗️ Sedlis Criteria (Adjuvant RT after Cervical Cancer Surgery)
After radical surgery for early cervical cancer (nodes/margins/parametria negative), check the Sedlis intermediate-risk criteria from LVSI, stromal invasion depth and tumour size to decide adjuvant pelvic radiation. Instant, browser-side.
Clinical takeaway
The Sedlis criteria apply only when nodes, margins and parametria are negative; positive findings are high-risk (Peters) and get chemoradiation.
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When to use
Decide adjuvant pelvic radiation for the intermediate-risk group after radical hysterectomy for early cervical cancer.
How it works
Meets if any: LVSI+ & deep 1/3 (any size); LVSI+ & mid 1/3 & ≥ 2 cm; LVSI+ & superficial 1/3 & ≥ 5 cm; LVSI− & mid/deep 1/3 & ≥ 4 cm.
Key points
- The Sedlis criteria apply only when nodes, margins and parametria are negative; positive findings are high-risk (Peters) and get chemoradiation.
- Meeting the criteria supports adjuvant pelvic external-beam radiation — GOG-92 showed roughly a 46% reduction in recurrence.
- Whether to add concurrent platinum chemotherapy for intermediate risk is individualised and varies by centre.
- NCCN notes risk factors are not strictly limited to the original Sedlis combinations.
References
Decision support for licensed clinicians only; not a substitute for clinical judgement, diagnosis or local protocols.
Worked calculation
The values below come from this tool's own example placeholders and are computed server-side with the formula shown on this page, so the arithmetic can be checked quickly. It demonstrates how to substitute values only — it is not clinical advice and not a real case.
| Lymphovascular space invasion (LVSI) | Positive |
|---|---|
| Cervical stromal invasion depth | Deep 1/3 (outer 1/3) |
| Maximum tumour diameter | 3.0 cm |
→Sedlis criteriaMet (adjuvant RT advised)
- Verdict：Meets Sedlis intermediate-risk criteria: LVSI-positive + deep 1/3 invasion (any size)
- Management direction：Adjuvant pelvic external-beam radiation is advised (GOG-92 showed ~ 46% recurrence reduction); whether to add concurrent platinum chemotherapy is individualised (some centres add chemo even for intermediate risk)
- Applicability：Applies after radical hysterectomy + pelvic lymphadenectomy in early-stage (IB–IIA) patients with negative nodes/margins/parametria; high-risk factors (Peters criteria) are instead treated with concurrent chemoradiation
| Lymphovascular space invasion (LVSI) | Negative |
|---|---|
| Cervical stromal invasion depth | Superficial 1/3 |
| Maximum tumour diameter | 3.0 cm |
→Sedlis criteriaNot met
- Verdict：Does not meet any Sedlis combination (LVSI/depth/size below threshold)
- Management direction：Intermediate risk not reached: generally observation/follow-up; if high-risk factors are present (positive parametria/nodes/margins, Peters criteria) treat as high-risk with concurrent chemoradiation
- Applicability：Applies after radical hysterectomy + pelvic lymphadenectomy in early-stage (IB–IIA) patients with negative nodes/margins/parametria; high-risk factors (Peters criteria) are instead treated with concurrent chemoradiation
Frequently asked questions
- What is Sedlis Criteria (Adjuvant RT after Cervical Cancer Surgery)?
- After radical surgery for early cervical cancer (nodes/margins/parametria negative), check the Sedlis intermediate-risk criteria from LVSI, stromal invasion depth and tumour size to decide adjuvant pelvic radiation. Instant, browser-side.
- How is Sedlis Criteria (Adjuvant RT after Cervical Cancer Surgery) calculated? What is the core formula?
- Meets if any: LVSI+ & deep 1/3 (any size); LVSI+ & mid 1/3 & ≥ 2 cm; LVSI+ & superficial 1/3 & ≥ 5 cm; LVSI− & mid/deep 1/3 & ≥ 4 cm.
- When is Sedlis Criteria (Adjuvant RT after Cervical Cancer Surgery) used?
- Decide adjuvant pelvic radiation for the intermediate-risk group after radical hysterectomy for early cervical cancer.
- What are the key clinical points for Sedlis Criteria (Adjuvant RT after Cervical Cancer Surgery)?
- The Sedlis criteria apply only when nodes, margins and parametria are negative; positive findings are high-risk (Peters) and get chemoradiation. Meeting the criteria supports adjuvant pelvic external-beam radiation — GOG-92 showed roughly a 46% reduction in recurrence. Whether to add concurrent platinum chemotherapy for intermediate risk is individualised and varies by centre. NCCN notes risk factors are not strictly limited to the original Sedlis combinations.
- What are the limits and cautions when using Sedlis Criteria (Adjuvant RT after Cervical Cancer Surgery)?
- For licensed clinicians and clinical researchers. Interpret results with history, investigations and local protocols; not a diagnosis or prescription, and not a substitute for multidisciplinary decision-making or local guidelines.
- How is Sedlis Criteria (Adjuvant RT after Cervical Cancer Surgery) calculated in practice? Can you show a worked example?
- Inputs: Lymphovascular space invasion (LVSI) Positive, Cervical stromal invasion depth Deep 1/3 (outer 1/3), Maximum tumour diameter 3.0 cm → Result: Sedlis criteria Met (adjuvant RT advised)（Verdict: Meets Sedlis intermediate-risk criteria: LVSI-positive + deep 1/3 invasion (any size), Management direction: Adjuvant pelvic external-beam radiation is advised (GOG-92 showed ~ 46% recurrence reduction); whether to add concurrent platinum chemotherapy is individualised (some centres add chemo even for intermediate risk), Applicability: Applies after radical hysterectomy + pelvic lymphadenectomy in early-stage (IB–IIA) patients with negative nodes/margins/parametria; high-risk factors (Peters criteria) are instead treated with concurrent chemoradiation） Inputs: Lymphovascular space invasion (LVSI) Negative, Cervical stromal invasion depth Superficial 1/3, Maximum tumour diameter 3.0 cm → Result: Sedlis criteria Not met（Verdict: Does not meet any Sedlis combination (LVSI/depth/size below threshold), Management direction: Intermediate risk not reached: generally observation/follow-up; if high-risk factors are present (positive parametria/nodes/margins, Peters criteria) treat as high-risk with concurrent chemoradiation, Applicability: Applies after radical hysterectomy + pelvic lymphadenectomy in early-stage (IB–IIA) patients with negative nodes/margins/parametria; high-risk factors (Peters criteria) are instead treated with concurrent chemoradiation）