📐 Antibiotic PK/PD Dosing Strategy
PK/PD targets and optimised dosing strategies for time-dependent, concentration-dependent and AUC-type antibiotics — extended infusion, once-daily dosing and AUC-based dosing. Browser-side.
Antibiotic PK/PD Dosing Strategy
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When to use
Choose a dosing strategy that matches the drug's PK/PD class to improve efficacy and suppress resistance.
How it works
Time-dependent (β-lactams) maximise fT > MIC; concentration-dependent (aminoglycosides/quinolones) maximise Cmax/MIC; AUC-type (vancomycin) maximise AUC/MIC.
Key points
- Extend or continuously infuse β-lactams in severe/high-MIC infection.
- Give aminoglycosides once-daily to raise the peak and exploit the PAE.
- Targets are MIC-based — account for the isolate MIC and tissue penetration.
- Augmented renal clearance needs higher doses / TDM.
References
Decision support for licensed clinicians only; not a substitute for clinical judgement, diagnosis or local protocols.