🎗️ Endometrial Cancer Mayo Lymphadenectomy Indication
Use the Mayo criteria (histology, grade, myometrial invasion, tumour size) to judge whether an endometrioid adenocarcinoma can safely be spared lymphadenectomy. Instant, browser-side.
Clinical takeaway
The low-risk group has roughly 1–5% nodal metastasis and ~ 99% 5-year survival, and can omit systematic dissection without a survival cost.
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When to use
Identify the low-risk endometrioid endometrial cancer group that can omit systematic lymphadenectomy.
How it works
Low-risk = endometrioid, G1–2, myometrial invasion ≤ 50%, diameter ≤ 2 cm (or no myometrial invasion at any size/grade). Any of G3 / > 50% invasion / > 2 cm / non-endometrioid = at-risk.
Key points
- The low-risk group has roughly 1–5% nodal metastasis and ~ 99% 5-year survival, and can omit systematic dissection without a survival cost.
- The at-risk group has roughly 6.4% nodal metastasis and warrants pelvic ± para-aortic dissection or sentinel-node biopsy.
- Non-endometrioid histology (serous/clear-cell/carcinosarcoma) is high-risk regardless and needs full staging.
- Contemporary practice increasingly replaces systematic lymphadenectomy with sentinel-node mapping.
References
Decision support for licensed clinicians only; not a substitute for clinical judgement, diagnosis or local protocols.
Worked calculation
The values below come from this tool's own example placeholders and are computed server-side with the formula shown on this page, so the arithmetic can be checked quickly. It demonstrates how to substitute values only — it is not clinical advice and not a real case.
| Histology | Endometrioid adenocarcinoma |
|---|---|
| Grade | G1–2 |
| Myometrial invasion depth | No myometrial invasion (0%) |
| Maximum primary tumour diameter | ≤ 2 cm |
→LymphadenectomyCan be omitted
- Verdict：Low-risk: Endometrioid, no myometrial invasion (0%) — low-risk at any size/grade (nodal metastasis ~ 1–5%, 5-year survival ~ 99%)
- Management direction：Systematic pelvic/para-aortic lymphadenectomy can be safely omitted (no survival impact); sentinel-node mapping now commonly replaces it
- Notes：Mayo criteria (Mariani 2000/2008): low-risk = endometrioid, G1–2, myometrial invasion ≤ 50%, diameter ≤ 2 cm (or no myometrial invasion, any size/grade); high-risk (> 50% invasion / G3 / > 2 cm / non-endometrioid) needs node assessment. Contemporary practice often replaces systematic dissection with sentinel-node biopsy
| Histology | Non-endometrioid (serous/clear-cell/carcinosarcoma etc.) |
|---|---|
| Grade | G3 |
| Myometrial invasion depth | > 50% (outer half) |
| Maximum primary tumour diameter | > 2 cm |
→LymphadenectomyDissection/assessment advised
- Verdict：High-risk (at-risk): Non-endometrioid (serous/clear-cell/carcinosarcoma etc.) is high-risk histology and needs systematic staging / node assessment (nodal metastasis ~ 6.4%)
- Management direction：Systematic pelvic ± para-aortic lymphadenectomy is advised, or sentinel-node biopsy to complete staging
- Notes：Mayo criteria (Mariani 2000/2008): low-risk = endometrioid, G1–2, myometrial invasion ≤ 50%, diameter ≤ 2 cm (or no myometrial invasion, any size/grade); high-risk (> 50% invasion / G3 / > 2 cm / non-endometrioid) needs node assessment. Contemporary practice often replaces systematic dissection with sentinel-node biopsy
Frequently asked questions
- What is Endometrial Cancer Mayo Lymphadenectomy Indication?
- Use the Mayo criteria (histology, grade, myometrial invasion, tumour size) to judge whether an endometrioid adenocarcinoma can safely be spared lymphadenectomy. Instant, browser-side.
- How is Endometrial Cancer Mayo Lymphadenectomy Indication calculated? What is the core formula?
- Low-risk = endometrioid, G1–2, myometrial invasion ≤ 50%, diameter ≤ 2 cm (or no myometrial invasion at any size/grade). Any of G3 / > 50% invasion / > 2 cm / non-endometrioid = at-risk.
- When is Endometrial Cancer Mayo Lymphadenectomy Indication used?
- Identify the low-risk endometrioid endometrial cancer group that can omit systematic lymphadenectomy.
- What are the key clinical points for Endometrial Cancer Mayo Lymphadenectomy Indication?
- The low-risk group has roughly 1–5% nodal metastasis and ~ 99% 5-year survival, and can omit systematic dissection without a survival cost. The at-risk group has roughly 6.4% nodal metastasis and warrants pelvic ± para-aortic dissection or sentinel-node biopsy. Non-endometrioid histology (serous/clear-cell/carcinosarcoma) is high-risk regardless and needs full staging. Contemporary practice increasingly replaces systematic lymphadenectomy with sentinel-node mapping.
- What are the limits and cautions when using Endometrial Cancer Mayo Lymphadenectomy Indication?
- For licensed clinicians and clinical researchers. Interpret results with history, investigations and local protocols; not a diagnosis or prescription, and not a substitute for multidisciplinary decision-making or local guidelines.
- How is Endometrial Cancer Mayo Lymphadenectomy Indication calculated in practice? Can you show a worked example?
- Inputs: Histology Endometrioid adenocarcinoma, Grade G1–2, Myometrial invasion depth No myometrial invasion (0%), Maximum primary tumour diameter ≤ 2 cm → Result: Lymphadenectomy Can be omitted（Verdict: Low-risk: Endometrioid, no myometrial invasion (0%) — low-risk at any size/grade (nodal metastasis ~ 1–5%, 5-year survival ~ 99%), Management direction: Systematic pelvic/para-aortic lymphadenectomy can be safely omitted (no survival impact); sentinel-node mapping now commonly replaces it, Notes: Mayo criteria (Mariani 2000/2008): low-risk = endometrioid, G1–2, myometrial invasion ≤ 50%, diameter ≤ 2 cm (or no myometrial invasion, any size/grade); high-risk (> 50% invasion / G3 / > 2 cm / non-endometrioid) needs node assessment. Contemporary practice often replaces systematic dissection with sentinel-node biopsy） Inputs: Histology Non-endometrioid (serous/clear-cell/carcinosarcoma etc.), Grade G3, Myometrial invasion depth > 50% (outer half), Maximum primary tumour diameter > 2 cm → Result: Lymphadenectomy Dissection/assessment advised（Verdict: High-risk (at-risk): Non-endometrioid (serous/clear-cell/carcinosarcoma etc.) is high-risk histology and needs systematic staging / node assessment (nodal metastasis ~ 6.4%), Management direction: Systematic pelvic ± para-aortic lymphadenectomy is advised, or sentinel-node biopsy to complete staging, Notes: Mayo criteria (Mariani 2000/2008): low-risk = endometrioid, G1–2, myometrial invasion ≤ 50%, diameter ≤ 2 cm (or no myometrial invasion, any size/grade); high-risk (> 50% invasion / G3 / > 2 cm / non-endometrioid) needs node assessment. Contemporary practice often replaces systematic dissection with sentinel-node biopsy）