🫀 Lille Model (Alcoholic Hepatitis Steroid Response)
Predict corticosteroid response in severe alcoholic hepatitis with the Lille model.
Clinical takeaway
Calculated after 7 days of corticosteroids.
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When to use
Decide whether to continue steroids after 7 days.
How it works
Uses age, albumin (g/L), bilirubin at day 0 and day 7 (µmol/L), prothrombin time and renal insufficiency; score = exp(−R)/(1+exp(−R)). > 0.45 = non-responder.
Key points
- Calculated after 7 days of corticosteroids.
- > 0.45 identifies non-responders with poor 6-month survival.
- Non-response prompts stopping steroids and reassessment.
References
Decision support for licensed clinicians only; not a substitute for clinical judgement, diagnosis or local protocols.
Worked calculation
The values below come from this tool's own example placeholders and are computed server-side with the formula shown on this page, so the arithmetic can be checked quickly. It demonstrates how to substitute values only — it is not clinical advice and not a real case.
| Age | 50 years |
|---|---|
| Albumin (day 0) | 28 g/L |
| Bilirubin (day 0) | 250 µmol/L |
| Bilirubin (day 7) | 200 µmol/L |
| Prothrombin time | 20 s |
| Renal insufficiency (Cr > 1.3 mg/dL) | No |
→Lille score0.220
- Interpretation：≤ 0.45 — responder; continue corticosteroids
- Note：Calculated after 7 days of corticosteroids; non-responders have poor 6-month survival.
| Age | 50 years |
|---|---|
| Albumin (day 0) | 28 g/L |
| Bilirubin (day 0) | 250 µmol/L |
| Bilirubin (day 7) | 200 µmol/L |
| Prothrombin time | 20 s |
| Renal insufficiency (Cr > 1.3 mg/dL) | Yes |
→Lille score0.258
- Interpretation：≤ 0.45 — responder; continue corticosteroids
- Note：Calculated after 7 days of corticosteroids; non-responders have poor 6-month survival.
Frequently asked questions
- What is Lille Model (Alcoholic Hepatitis Steroid Response)?
- Predict corticosteroid response in severe alcoholic hepatitis with the Lille model.
- How is Lille Model (Alcoholic Hepatitis Steroid Response) calculated? What is the core formula?
- Uses age, albumin (g/L), bilirubin at day 0 and day 7 (µmol/L), prothrombin time and renal insufficiency; score = exp(−R)/(1+exp(−R)). > 0.45 = non-responder.
- When is Lille Model (Alcoholic Hepatitis Steroid Response) used?
- Decide whether to continue steroids after 7 days.
- What are the key clinical points for Lille Model (Alcoholic Hepatitis Steroid Response)?
- Calculated after 7 days of corticosteroids. > 0.45 identifies non-responders with poor 6-month survival. Non-response prompts stopping steroids and reassessment.
- What are the limits and cautions when using Lille Model (Alcoholic Hepatitis Steroid Response)?
- For licensed clinicians and clinical researchers. Interpret results with history, investigations and local protocols; not a diagnosis or prescription, and not a substitute for multidisciplinary decision-making or local guidelines.
- How is Lille Model (Alcoholic Hepatitis Steroid Response) calculated in practice? Can you show a worked example?
- Inputs: Age 50 years, Albumin (day 0) 28 g/L, Bilirubin (day 0) 250 µmol/L, Bilirubin (day 7) 200 µmol/L, Prothrombin time 20 s, Renal insufficiency (Cr > 1.3 mg/dL) No → Result: Lille score 0.220（Interpretation: ≤ 0.45 — responder; continue corticosteroids, Note: Calculated after 7 days of corticosteroids; non-responders have poor 6-month survival.） Inputs: Age 50 years, Albumin (day 0) 28 g/L, Bilirubin (day 0) 250 µmol/L, Bilirubin (day 7) 200 µmol/L, Prothrombin time 20 s, Renal insufficiency (Cr > 1.3 mg/dL) Yes → Result: Lille score 0.258（Interpretation: ≤ 0.45 — responder; continue corticosteroids, Note: Calculated after 7 days of corticosteroids; non-responders have poor 6-month survival.）