🫀 Lille Model (Alcoholic Hepatitis Steroid Response)
Predict corticosteroid response in severe alcoholic hepatitis with the Lille model.
Lille Model (Alcoholic Hepatitis Steroid Response)
Age (years)
Albumin (day 0) (g/L)
Bilirubin (day 0) (µmol/L)
Bilirubin (day 7) (µmol/L)
Prothrombin time (s)
Renal insufficiency (Cr > 1.3 mg/dL)
When to use
Decide whether to continue steroids after 7 days.
How it works
Uses age, albumin (g/L), bilirubin at day 0 and day 7 (µmol/L), prothrombin time and renal insufficiency; score = exp(−R)/(1+exp(−R)). > 0.45 = non-responder.
Key points
- Calculated after 7 days of corticosteroids.
- > 0.45 identifies non-responders with poor 6-month survival.
- Non-response prompts stopping steroids and reassessment.
References
Decision support for licensed clinicians only; not a substitute for clinical judgement, diagnosis or local protocols.