🧪 Albumin-Corrected Anion Gap
Correct the anion gap for hypoalbuminaemia.
Clinical takeaway
Each 1 g/dL fall in albumin lowers AG by ~2.5.
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When to use
Avoid missing a high-anion-gap acidosis when albumin is low.
How it works
Corrected AG = AG + 2.5 × (4.0 − albumin g/dL). Reference ~8–12 mmol/L.
Key points
- Each 1 g/dL fall in albumin lowers AG by ~2.5.
- Hypoalbuminaemia can mask a metabolic acidosis.
- Pair with the delta ratio for mixed disorders.
References
Decision support for licensed clinicians only; not a substitute for clinical judgement, diagnosis or local protocols.
Worked calculation
The values below come from this tool's own example placeholders and are computed server-side with the formula shown on this page, so the arithmetic can be checked quickly. It demonstrates how to substitute values only — it is not clinical advice and not a real case.
| Measured anion gap | 10 mmol/L |
|---|---|
| Albumin | 2.0 g/dL |
→Corrected AG15.0mmol/L
- Reference：~8–12 mmol/L
- Formula：AG + 2.5 × (4.0 − albumin)
Frequently asked questions
- What is Albumin-Corrected Anion Gap?
- Correct the anion gap for hypoalbuminaemia.
- How is Albumin-Corrected Anion Gap calculated? What is the core formula?
- Corrected AG = AG + 2.5 × (4.0 − albumin g/dL). Reference ~8–12 mmol/L.
- When is Albumin-Corrected Anion Gap used?
- Avoid missing a high-anion-gap acidosis when albumin is low.
- What are the key clinical points for Albumin-Corrected Anion Gap?
- Each 1 g/dL fall in albumin lowers AG by ~2.5. Hypoalbuminaemia can mask a metabolic acidosis. Pair with the delta ratio for mixed disorders.
- What are the limits and cautions when using Albumin-Corrected Anion Gap?
- For licensed clinicians and clinical researchers. Interpret results with history, investigations and local protocols; not a diagnosis or prescription, and not a substitute for multidisciplinary decision-making or local guidelines.
- How is Albumin-Corrected Anion Gap calculated in practice? Can you show a worked example?
- Inputs: Measured anion gap 10 mmol/L, Albumin 2.0 g/dL → Result: Corrected AG 15.0 mmol/L（Reference: ~8–12 mmol/L, Formula: AG + 2.5 × (4.0 − albumin)）