🧬 Tumour Lysis Syndrome (TLS) Prophylaxis
Tumour lysis syndrome (TLS) risk stratification, prophylaxis (hydration, allopurinol, rasburicase), monitoring and the Cairo-Bishop definition. Browser-side.
Tumour Lysis Syndrome (TLS) Prophylaxis
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When to use
Stratify TLS risk before chemotherapy and choose the appropriate prophylaxis tier.
How it works
High risk > 5%, intermediate 1–5%, low < 1%. Hydration is the cornerstone; allopurinol for intermediate, rasburicase for high risk.
Key points
- Hydration (~3 L/m²/day) underpins all prophylaxis.
- Exclude G6PD deficiency before rasburicase (haemolysis).
- Do not combine rasburicase with allopurinol; do not replace asymptomatic hypocalcaemia.
- Urine alkalinisation is no longer routine.
References
Decision support for licensed clinicians only; not a substitute for clinical judgement, diagnosis or local protocols.