🩸 Sokal Index (Chronic Myeloid Leukemia)
The Sokal index is a classic pre-treatment prognostic score for newly diagnosed chronic-phase chronic myeloid leukemia (CML), derived from age, spleen size, platelet count, and peripheral blasts.
The index predates tyrosine kinase inhibitors, so it is now interpreted alongside the Hasford/Euro, EUTOS, and ELTS scores rather than used in isolation (original synthesis · not guideline verbatim).
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When to use
Enter age, spleen size below the costal margin (cm), platelet count, and peripheral blood blast percentage; the tool returns the relative-risk value and risk group.
How it works
Exp[0.0116 × (age − 43.4) + 0.0345 × (spleen − 7.51) + 0.188 × ((platelets/700)² − 0.563) + 0.0887 × (blasts − 2.10)]. <0.8 low, 0.8–1.2 intermediate, >1.2 high risk.
Key points
- The index predates tyrosine kinase inhibitors, so it is now interpreted alongside the Hasford/Euro, EUTOS, and ELTS scores rather than used in isolation (original synthesis · not guideline verbatim).
- Spleen size is the maximum distance palpable below the costal margin in centimetres, measured before any treatment.
- High-risk patients may be considered for an upfront second-generation TKI or closer molecular monitoring, recognizing the score's limited discrimination in the TKI era.
References
Worked calculation
The values below come from this tool's own example placeholders and are computed server-side with the formula shown on this page, so the arithmetic can be checked quickly. It demonstrates how to substitute values only — it is not clinical advice and not a real case.
| Age | 50 years |
|---|---|
| Spleen size (below costal margin) | 5 cm |
| Platelets | 400 ×10⁹/L |
| Peripheral blood blasts | 2 % |
→Sokal relative risk0.94
- Risk group：Intermediate risk
Frequently asked questions
- What is Sokal Index (Chronic Myeloid Leukemia)?
- The Sokal index is a classic pre-treatment prognostic score for newly diagnosed chronic-phase chronic myeloid leukemia (CML), derived from age, spleen size, platelet count, and peripheral blasts.
- How is Sokal Index (Chronic Myeloid Leukemia) calculated? What is the core formula?
- Exp[0.0116 × (age − 43.4) + 0.0345 × (spleen − 7.51) + 0.188 × ((platelets/700)² − 0.563) + 0.0887 × (blasts − 2.10)]. <0.8 low, 0.8–1.2 intermediate, >1.2 high risk.
- When is Sokal Index (Chronic Myeloid Leukemia) used?
- Enter age, spleen size below the costal margin (cm), platelet count, and peripheral blood blast percentage; the tool returns the relative-risk value and risk group.
- What are the key clinical points for Sokal Index (Chronic Myeloid Leukemia)?
- The index predates tyrosine kinase inhibitors, so it is now interpreted alongside the Hasford/Euro, EUTOS, and ELTS scores rather than used in isolation (original synthesis · not guideline verbatim). Spleen size is the maximum distance palpable below the costal margin in centimetres, measured before any treatment. High-risk patients may be considered for an upfront second-generation TKI or closer molecular monitoring, recognizing the score's limited discrimination in the TKI era.
- What are the limits and cautions when using Sokal Index (Chronic Myeloid Leukemia)?
- For licensed clinicians and clinical researchers. Interpret results with history, investigations and local protocols; not a diagnosis or prescription, and not a substitute for multidisciplinary decision-making or local guidelines.
- How is Sokal Index (Chronic Myeloid Leukemia) calculated in practice? Can you show a worked example?
- Inputs: Age 50 years, Spleen size (below costal margin) 5 cm, Platelets 400 ×10⁹/L, Peripheral blood blasts 2 % → Result: Sokal relative risk 0.94（Risk group: Intermediate risk）