🫀 NAFLD Fibrosis Score (NFS)
Predict advanced fibrosis in NAFLD/MASLD with the NAFLD Fibrosis Score (NFS).
Two cut-offs create low, indeterminate and high zones.
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When to use
Identify who needs elastography or hepatology referral in fatty liver disease.
How it works
NFS = −1.675 + 0.037·age + 0.094·BMI + 1.13·(IFG/DM) + 0.99·(AST/ALT) − 0.013·platelets − 0.66·albumin. < −1.455 excludes advanced fibrosis; > 0.676 suggests it.
Key points
- Two cut-offs create low, indeterminate and high zones.
- Less accurate under 35 or over 65 years.
- Combine with FIB-4 and elastography.
References
Worked calculation
The values below come from this tool's own example placeholders and are computed server-side with the formula shown on this page, so the arithmetic can be checked quickly. It demonstrates how to substitute values only — it is not clinical advice and not a real case.
| Age | 55 years |
|---|---|
| BMI | 30 kg/m² |
| Impaired fasting glucose / diabetes | No |
| AST | 50 U/L |
| ALT | 40 U/L |
| Platelets | 200 ×10⁹/L |
| Albumin | 4.0 g/dL |
→NFS-0.82
- Interpretation：Indeterminate zone
| Age | 55 years |
|---|---|
| BMI | 30 kg/m² |
| Impaired fasting glucose / diabetes | Yes |
| AST | 50 U/L |
| ALT | 40 U/L |
| Platelets | 200 ×10⁹/L |
| Albumin | 4.0 g/dL |
→NFS0.31
- Interpretation：Indeterminate zone
Frequently asked questions
- What is NAFLD Fibrosis Score (NFS)?
- Predict advanced fibrosis in NAFLD/MASLD with the NAFLD Fibrosis Score (NFS).
- How is NAFLD Fibrosis Score (NFS) calculated? What is the core formula?
- NFS = −1.675 + 0.037·age + 0.094·BMI + 1.13·(IFG/DM) + 0.99·(AST/ALT) − 0.013·platelets − 0.66·albumin. < −1.455 excludes advanced fibrosis; > 0.676 suggests it.
- When is NAFLD Fibrosis Score (NFS) used?
- Identify who needs elastography or hepatology referral in fatty liver disease.
- What are the key clinical points for NAFLD Fibrosis Score (NFS)?
- Two cut-offs create low, indeterminate and high zones. Less accurate under 35 or over 65 years. Combine with FIB-4 and elastography.
- What are the limits and cautions when using NAFLD Fibrosis Score (NFS)?
- For licensed clinicians and clinical researchers. Interpret results with history, investigations and local protocols; not a diagnosis or prescription, and not a substitute for multidisciplinary decision-making or local guidelines.
- How is NAFLD Fibrosis Score (NFS) calculated in practice? Can you show a worked example?
- Inputs: Age 55 years, BMI 30 kg/m², Impaired fasting glucose / diabetes No, AST 50 U/L, ALT 40 U/L, Platelets 200 ×10⁹/L, Albumin 4.0 g/dL → Result: NFS -0.82（Interpretation: Indeterminate zone） Inputs: Age 55 years, BMI 30 kg/m², Impaired fasting glucose / diabetes Yes, AST 50 U/L, ALT 40 U/L, Platelets 200 ×10⁹/L, Albumin 4.0 g/dL → Result: NFS 0.31（Interpretation: Indeterminate zone）