🫀 Milan Criteria (HCC Transplant)
Check whether hepatocellular carcinoma meets the Milan criteria, the classic morphologic standard for liver transplant candidacy.
Within-criteria transplant gives ~ 70% 5-year survival.
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When to use
Assess transplant eligibility in HCC based on tumor burden and spread.
How it works
Within Milan = single lesion ≤ 5 cm, or ≤ 3 lesions each ≤ 3 cm, with no macrovascular invasion and no extrahepatic spread.
Key points
- Within-criteria transplant gives ~ 70% 5-year survival.
- Outside-criteria patients may qualify via expanded criteria (UCSF, up-to-7) or after downstaging.
- Macrovascular invasion or extrahepatic spread is usually a contraindication.
References
Worked calculation
The values below come from this tool's own example placeholders and are computed server-side with the formula shown on this page, so the arithmetic can be checked quickly. It demonstrates how to substitute values only — it is not clinical advice and not a real case.
| Number of tumors | 1 lesions |
|---|---|
| Largest tumor diameter | 4 cm |
| Macrovascular invasion | No |
| Extrahepatic spread | No |
→Milan criteriaWithin criteria
- Tumors：1 lesion(s) / largest 4.0 cm
- Vascular invasion / extrahepatic spread：Absent
| Number of tumors | 1 lesions |
|---|---|
| Largest tumor diameter | 4 cm |
| Macrovascular invasion | Yes |
| Extrahepatic spread | Yes |
→Milan criteriaOutside criteria
- Tumors：1 lesion(s) / largest 4.0 cm
- Vascular invasion / extrahepatic spread：Present
Frequently asked questions
- What is Milan Criteria (HCC Transplant)?
- Check whether hepatocellular carcinoma meets the Milan criteria, the classic morphologic standard for liver transplant candidacy.
- How is Milan Criteria (HCC Transplant) calculated? What is the core formula?
- Within Milan = single lesion ≤ 5 cm, or ≤ 3 lesions each ≤ 3 cm, with no macrovascular invasion and no extrahepatic spread.
- When is Milan Criteria (HCC Transplant) used?
- Assess transplant eligibility in HCC based on tumor burden and spread.
- What are the key clinical points for Milan Criteria (HCC Transplant)?
- Within-criteria transplant gives ~ 70% 5-year survival. Outside-criteria patients may qualify via expanded criteria (UCSF, up-to-7) or after downstaging. Macrovascular invasion or extrahepatic spread is usually a contraindication.
- What are the limits and cautions when using Milan Criteria (HCC Transplant)?
- For licensed clinicians and clinical researchers. Interpret results with history, investigations and local protocols; not a diagnosis or prescription, and not a substitute for multidisciplinary decision-making or local guidelines.
- How is Milan Criteria (HCC Transplant) calculated in practice? Can you show a worked example?
- Inputs: Number of tumors 1 lesions, Largest tumor diameter 4 cm, Macrovascular invasion No, Extrahepatic spread No → Result: Milan criteria Within criteria（Tumors: 1 lesion(s) / largest 4.0 cm, Vascular invasion / extrahepatic spread: Absent） Inputs: Number of tumors 1 lesions, Largest tumor diameter 4 cm, Macrovascular invasion Yes, Extrahepatic spread Yes → Result: Milan criteria Outside criteria（Tumors: 1 lesion(s) / largest 4.0 cm, Vascular invasion / extrahepatic spread: Present）