🫀 Liver Function Test Pattern Interpretation
Pattern-based interpretation of abnormal liver function tests using the R factor, bilirubin fractions, synthetic markers and isolated abnormalities. Browser-side.
Albumin and INR reflect hepatic synthetic reserve.
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When to use
Classify liver injury as hepatocellular, cholestatic or mixed to direct further testing.
How it works
R = (ALT/ULN) / (ALP/ULN): hepatocellular > 5, cholestatic < 2, mixed 2–5.
Key points
- Albumin and INR reflect hepatic synthetic reserve.
- Conjugated bilirubin > 20% of total suggests hepatobiliary disease.
- Isolated ALP rise: check GGT to separate hepatic from bony source.
- Isolated indirect bilirubin is usually Gilbert syndrome.
References
Worked calculation
The values below come from this tool's own example placeholders and are computed server-side with the formula shown on this page, so the arithmetic can be checked quickly. It demonstrates how to substitute values only — it is not clinical advice and not a real case.
| View | R-factor pattern |
|---|
→PatternR-factor pattern
- R factor：R = (ALT/ULN) / (ALP/ULN)
- Hepatocellular：R > 5: viral/drug/alcohol/ischaemic/autoimmune/fatty liver
- Cholestatic：R < 2: obstruction/PBC/PSC/drug/infiltration
| View | Isolated abnormality |
|---|
→PatternIsolated abnormality
- Isolated ALP ↑：Check GGT to separate hepatic vs bony source; pregnancy/growth
- Isolated GGT ↑：Alcohol, drug induction; sensitive but non-specific
- Isolated bilirubin ↑：Usually Gilbert (indirect, rest normal)
Frequently asked questions
- What is Liver Function Test Pattern Interpretation?
- Pattern-based interpretation of abnormal liver function tests using the R factor, bilirubin fractions, synthetic markers and isolated abnormalities. Browser-side.
- How is Liver Function Test Pattern Interpretation calculated? What is the core formula?
- R = (ALT/ULN) / (ALP/ULN): hepatocellular > 5, cholestatic < 2, mixed 2–5.
- When is Liver Function Test Pattern Interpretation used?
- Classify liver injury as hepatocellular, cholestatic or mixed to direct further testing.
- What are the key clinical points for Liver Function Test Pattern Interpretation?
- Albumin and INR reflect hepatic synthetic reserve. Conjugated bilirubin > 20% of total suggests hepatobiliary disease. Isolated ALP rise: check GGT to separate hepatic from bony source. Isolated indirect bilirubin is usually Gilbert syndrome.
- What are the limits and cautions when using Liver Function Test Pattern Interpretation?
- For licensed clinicians and clinical researchers. Interpret results with history, investigations and local protocols; not a diagnosis or prescription, and not a substitute for multidisciplinary decision-making or local guidelines.
- How is Liver Function Test Pattern Interpretation calculated in practice? Can you show a worked example?
- Inputs: View R-factor pattern → Result: Pattern R-factor pattern（R factor: R = (ALT/ULN) / (ALP/ULN), Hepatocellular: R > 5: viral/drug/alcohol/ischaemic/autoimmune/fatty liver, Cholestatic: R < 2: obstruction/PBC/PSC/drug/infiltration） Inputs: View Isolated abnormality → Result: Pattern Isolated abnormality（Isolated ALP ↑: Check GGT to separate hepatic vs bony source; pregnancy/growth, Isolated GGT ↑: Alcohol, drug induction; sensitive but non-specific, Isolated bilirubin ↑: Usually Gilbert (indirect, rest normal)）