🩸 ISTH DIC Score (Overt DIC)
Diagnose overt disseminated intravascular coagulation with the ISTH scoring algorithm.
Clinical takeaway
Only apply when an underlying DIC-associated disorder is present.
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When to use
Confirm overt DIC in a patient with a predisposing condition.
How it works
Platelets, D-dimer/FDP, prolonged PT and fibrinogen are scored; total ≥ 5 is compatible with overt DIC.
Key points
- Only apply when an underlying DIC-associated disorder is present.
- Score < 5 does not exclude evolving (non-overt) DIC — repeat.
- Treat the underlying cause alongside supportive haemostatic therapy.
References
Decision support for licensed clinicians only; not a substitute for clinical judgement, diagnosis or local protocols.
Worked calculation
The values below come from this tool's own example placeholders and are computed server-side with the formula shown on this page, so the arithmetic can be checked quickly. It demonstrates how to substitute values only — it is not clinical advice and not a real case.
| Platelet count | > 100 (0) |
|---|---|
| Fibrin marker (D-dimer/FDP) | No increase (0) |
| PT prolongation | < 3 s (0) |
| Fibrinogen | ≥ 1 g/L (0) |
→ISTH DIC0/8
- Interpretation：< 5 — not suggestive of overt DIC; consider repeating if suspicion persists.
| Platelet count | < 50 (2) |
|---|---|
| Fibrin marker (D-dimer/FDP) | Strong increase (3) |
| PT prolongation | > 6 s (2) |
| Fibrinogen | < 1 g/L (1) |
→ISTH DIC8/8
- Interpretation：≥ 5 — compatible with overt DIC; repeat scoring daily.
Frequently asked questions
- What is ISTH DIC Score (Overt DIC)?
- Diagnose overt disseminated intravascular coagulation with the ISTH scoring algorithm.
- How is ISTH DIC Score (Overt DIC) calculated? What is the core formula?
- Platelets, D-dimer/FDP, prolonged PT and fibrinogen are scored; total ≥ 5 is compatible with overt DIC.
- When is ISTH DIC Score (Overt DIC) used?
- Confirm overt DIC in a patient with a predisposing condition.
- What are the key clinical points for ISTH DIC Score (Overt DIC)?
- Only apply when an underlying DIC-associated disorder is present. Score < 5 does not exclude evolving (non-overt) DIC — repeat. Treat the underlying cause alongside supportive haemostatic therapy.
- What are the limits and cautions when using ISTH DIC Score (Overt DIC)?
- For licensed clinicians and clinical researchers. Interpret results with history, investigations and local protocols; not a diagnosis or prescription, and not a substitute for multidisciplinary decision-making or local guidelines.
- How is ISTH DIC Score (Overt DIC) calculated in practice? Can you show a worked example?
- Inputs: Platelet count > 100 (0), Fibrin marker (D-dimer/FDP) No increase (0), PT prolongation < 3 s (0), Fibrinogen ≥ 1 g/L (0) → Result: ISTH DIC 0 /8（Interpretation: < 5 — not suggestive of overt DIC; consider repeating if suspicion persists.） Inputs: Platelet count < 50 (2), Fibrin marker (D-dimer/FDP) Strong increase (3), PT prolongation > 6 s (2), Fibrinogen < 1 g/L (1) → Result: ISTH DIC 8 /8（Interpretation: ≥ 5 — compatible with overt DIC; repeat scoring daily.）