🧬 International Prognostic Index (IPI, DLBCL)
Prognosticate aggressive lymphoma with the International Prognostic Index (IPI).
Clinical takeaway
Guides prognosis in the rituximab era (also see R-IPI/NCCN-IPI).
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When to use
Risk-stratify diffuse large B-cell lymphoma at diagnosis.
How it works
One point each for age > 60, stage III/IV, ECOG ≥ 2, elevated LDH, > 1 extranodal site. 0–1 low, 2 low-intermediate, 3 high-intermediate, 4–5 high.
Key points
- Guides prognosis in the rituximab era (also see R-IPI/NCCN-IPI).
- Higher scores correlate with lower survival.
- Used in trial stratification.
References
Decision support for licensed clinicians only; not a substitute for clinical judgement, diagnosis or local protocols.
Worked calculation
The values below come from this tool's own example placeholders and are computed server-side with the formula shown on this page, so the arithmetic can be checked quickly. It demonstrates how to substitute values only — it is not clinical advice and not a real case.
| Age > 60 | No |
|---|---|
| Ann Arbor stage III–IV | No |
| ECOG ≥ 2 | No |
| LDH > normal | No |
| > 1 extranodal site | No |
→IPI0/5
- Risk group：Low risk
| Age > 60 | Yes (+1) |
|---|---|
| Ann Arbor stage III–IV | Yes (+1) |
| ECOG ≥ 2 | Yes (+1) |
| LDH > normal | Yes (+1) |
| > 1 extranodal site | Yes (+1) |
→IPI5/5
- Risk group：High risk
Frequently asked questions
- What is International Prognostic Index (IPI, DLBCL)?
- Prognosticate aggressive lymphoma with the International Prognostic Index (IPI).
- How is International Prognostic Index (IPI, DLBCL) calculated? What is the core formula?
- One point each for age > 60, stage III/IV, ECOG ≥ 2, elevated LDH, > 1 extranodal site. 0–1 low, 2 low-intermediate, 3 high-intermediate, 4–5 high.
- When is International Prognostic Index (IPI, DLBCL) used?
- Risk-stratify diffuse large B-cell lymphoma at diagnosis.
- What are the key clinical points for International Prognostic Index (IPI, DLBCL)?
- Guides prognosis in the rituximab era (also see R-IPI/NCCN-IPI). Higher scores correlate with lower survival. Used in trial stratification.
- What are the limits and cautions when using International Prognostic Index (IPI, DLBCL)?
- For licensed clinicians and clinical researchers. Interpret results with history, investigations and local protocols; not a diagnosis or prescription, and not a substitute for multidisciplinary decision-making or local guidelines.
- How is International Prognostic Index (IPI, DLBCL) calculated in practice? Can you show a worked example?
- Inputs: Age > 60 No, Ann Arbor stage III–IV No, ECOG ≥ 2 No, LDH > normal No, > 1 extranodal site No → Result: IPI 0 /5（Risk group: Low risk） Inputs: Age > 60 Yes (+1), Ann Arbor stage III–IV Yes (+1), ECOG ≥ 2 Yes (+1), LDH > normal Yes (+1), > 1 extranodal site Yes (+1) → Result: IPI 5 /5（Risk group: High risk）