🩸 Hemolysis Marker Interpretation
Laboratory markers of haemolysis (LDH, haptoglobin, indirect bilirubin, reticulocytes, smear), intra- vs extravascular, DAT triage and causes. Browser-side.
LDH ↑ with haptoglobin ↓ is sensitive and specific for haemolysis.
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When to use
Confirm haemolysis, then classify by DAT (immune vs non-immune) and the intravascular/extravascular pattern to find the cause.
How it works
Haemolysis: LDH ↑ + haptoglobin ↓ + indirect bilirubin ↑ + reticulocytes ↑.
Key points
- LDH ↑ with haptoglobin ↓ is sensitive and specific for haemolysis.
- DAT separates immune (AIHA) from non-immune haemolysis.
- Schistocytes flag microangiopathic haemolysis (MAHA).
- MAHA needs urgent workup for TTP/HUS/DIC.
References
Worked calculation
The values below come from this tool's own example placeholders and are computed server-side with the formula shown on this page, so the arithmetic can be checked quickly. It demonstrates how to substitute values only — it is not clinical advice and not a real case.
| View | Lab markers |
|---|
→Key pointLab markers of haemolysis
- Increased：LDH ↑, indirect (unconjugated) bilirubin ↑, reticulocytes ↑
- Decreased：Haptoglobin ↓
- Smear：Schistocytes (MAHA), spherocytes (immune/hereditary), bite cells (G6PD)
| View | Common causes |
|---|
→Key pointCommon causes
- MAHA (schistocytes)：TTP/HUS, DIC, HELLP, malignant hypertension, mechanical valve → urgent differentiation
- Hereditary：G6PD deficiency (oxidative stress), hereditary spherocytosis, sickle/thalassaemia
- Acquired：Immune (AIHA), PNH, infection, drugs, microangiopathy
Frequently asked questions
- What is Hemolysis Marker Interpretation?
- Laboratory markers of haemolysis (LDH, haptoglobin, indirect bilirubin, reticulocytes, smear), intra- vs extravascular, DAT triage and causes. Browser-side.
- How is Hemolysis Marker Interpretation calculated? What is the core formula?
- Haemolysis: LDH ↑ + haptoglobin ↓ + indirect bilirubin ↑ + reticulocytes ↑.
- When is Hemolysis Marker Interpretation used?
- Confirm haemolysis, then classify by DAT (immune vs non-immune) and the intravascular/extravascular pattern to find the cause.
- What are the key clinical points for Hemolysis Marker Interpretation?
- LDH ↑ with haptoglobin ↓ is sensitive and specific for haemolysis. DAT separates immune (AIHA) from non-immune haemolysis. Schistocytes flag microangiopathic haemolysis (MAHA). MAHA needs urgent workup for TTP/HUS/DIC.
- What are the limits and cautions when using Hemolysis Marker Interpretation?
- For licensed clinicians and clinical researchers. Interpret results with history, investigations and local protocols; not a diagnosis or prescription, and not a substitute for multidisciplinary decision-making or local guidelines.
- How is Hemolysis Marker Interpretation calculated in practice? Can you show a worked example?
- Inputs: View Lab markers → Result: Key point Lab markers of haemolysis（Increased: LDH ↑, indirect (unconjugated) bilirubin ↑, reticulocytes ↑, Decreased: Haptoglobin ↓, Smear: Schistocytes (MAHA), spherocytes (immune/hereditary), bite cells (G6PD)） Inputs: View Common causes → Result: Key point Common causes（MAHA (schistocytes): TTP/HUS, DIC, HELLP, malignant hypertension, mechanical valve → urgent differentiation, Hereditary: G6PD deficiency (oxidative stress), hereditary spherocytosis, sickle/thalassaemia, Acquired: Immune (AIHA), PNH, infection, drugs, microangiopathy）