🧠 Cerebral Perfusion Pressure (CPP) & ICP Targets
Cerebral perfusion pressure (CPP = MAP − ICP) and intracranial-pressure targets in severe TBI and neurocritical care.
Cerebral Perfusion Pressure (CPP) & ICP Targets
Systolic BP SBP (mmHg)
Diastolic BP DBP (mmHg)
Intracranial pressure ICP (mmHg)
When to use
Use to compute CPP from blood pressure and ICP and to check it against Brain Trauma Foundation targets.
How it works
MAP = DBP + (SBP − DBP)/3; CPP = MAP − ICP; severe-TBI target CPP 60–70 mmHg; ICP > 22 mmHg triggers ICP-lowering therapy.
Key points
- Maintaining CPP > 70 with vasopressors raises ARDS and volume-overload risk — CPP is an optimization target, not 'higher is better' (original synthesis · not guideline verbatim).
- Zero the arterial transducer at the tragus (≈ foramen of Monro) so MAP/CPP reflect cerebral, not cardiac, level.
- When autoregulation is impaired, cerebral blood flow follows CPP passively, making both hypo- and hypertension hazardous.
References
- Carney N, et al. Brain Trauma Foundation severe-TBI guidelines, 4th ed. Neurosurgery 2017.
- Hawryluk GWJ, et al. ICP/CPP management consensus (SIBICC). Intensive Care Med 2019.
Decision support for licensed clinicians only; not a substitute for clinical judgement, diagnosis or local protocols.