🫀 ALBI Grade (Albumin-Bilirubin)
The ALBI (albumin-bilirubin) grade objectively measures hepatic functional reserve using only two laboratory values.
ALBI avoids the subjective ascites and encephalopathy components of Child-Pugh, making it more reproducible for HCC stratification (original synthesis · not guideline verbatim).
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When to use
Enter total bilirubin and albumin; the tool computes the ALBI score and assigns grade 1, 2, or 3.
How it works
ALBI score = 0.66 × log₁₀(bilirubin in μmol/L) − 0.085 × (albumin in g/L). Grade 1 ≤ −2.60, Grade 2 −2.60 to −1.39, Grade 3 > −1.39.
Key points
- ALBI avoids the subjective ascites and encephalopathy components of Child-Pugh, making it more reproducible for HCC stratification (original synthesis · not guideline verbatim).
- Grade is widely used to gauge tolerance of liver resection and transarterial chemoembolization.
- An ALBI-based modification of Child-Pugh (the ALBI grade within stage A) further separates prognosis in compensated cirrhosis.
References
- Johnson PJ, et al. Assessment of liver function in patients with hepatocellular carcinoma: the ALBI grade. J Clin Oncol. 2015.
- Hiraoka A, et al. Validation and potential of ALBI grade for HCC. Liver Cancer. 2017.
Worked calculation
The values below come from this tool's own example placeholders and are computed server-side with the formula shown on this page, so the arithmetic can be checked quickly. It demonstrates how to substitute values only — it is not clinical advice and not a real case.
| Total bilirubin | 20 μmol/L |
|---|---|
| Albumin | 38 g/L |
→ALBI gradeGrade 2
- ALBI score：-2.37
- Formula：0.66·log₁₀(bilirubin) − 0.085·albumin
Frequently asked questions
- What is ALBI Grade (Albumin-Bilirubin)?
- The ALBI (albumin-bilirubin) grade objectively measures hepatic functional reserve using only two laboratory values.
- How is ALBI Grade (Albumin-Bilirubin) calculated? What is the core formula?
- ALBI score = 0.66 × log₁₀(bilirubin in μmol/L) − 0.085 × (albumin in g/L). Grade 1 ≤ −2.60, Grade 2 −2.60 to −1.39, Grade 3 > −1.39.
- When is ALBI Grade (Albumin-Bilirubin) used?
- Enter total bilirubin and albumin; the tool computes the ALBI score and assigns grade 1, 2, or 3.
- What are the key clinical points for ALBI Grade (Albumin-Bilirubin)?
- ALBI avoids the subjective ascites and encephalopathy components of Child-Pugh, making it more reproducible for HCC stratification (original synthesis · not guideline verbatim). Grade is widely used to gauge tolerance of liver resection and transarterial chemoembolization. An ALBI-based modification of Child-Pugh (the ALBI grade within stage A) further separates prognosis in compensated cirrhosis.
- What are the limits and cautions when using ALBI Grade (Albumin-Bilirubin)?
- For licensed clinicians and clinical researchers. Interpret results with history, investigations and local protocols; not a diagnosis or prescription, and not a substitute for multidisciplinary decision-making or local guidelines.
- How is ALBI Grade (Albumin-Bilirubin) calculated in practice? Can you show a worked example?
- Inputs: Total bilirubin 20 μmol/L, Albumin 38 g/L → Result: ALBI grade Grade 2（ALBI score: -2.37, Formula: 0.66·log₁₀(bilirubin) − 0.085·albumin）