🎯 Therapeutic Drug Monitoring (TDM) Targets
Quick reference to therapeutic ranges, sampling timing and toxicity cues for commonly monitored drugs — digoxin, antiepileptics, lithium, vancomycin, aminoglycosides and more. Browser-side.
Units and assays vary between laboratories.
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When to use
Look up the target range and when to sample (trough/peak/steady state). Interpret levels with clinical efficacy and toxicity.
How it works
Examples: digoxin 0.5–2.0 ng/mL (HF 0.5–0.9); phenytoin total 10–20 µg/mL; lithium 0.6–1.0 mmol/L; vancomycin AUC/MIC 400–600.
Key points
- Units and assays vary between laboratories.
- Wrong sampling timing (before steady state, not a true trough/peak) causes misinterpretation.
- A subtherapeutic level with good clinical response need not be changed.
- For vancomycin and aminoglycosides see the dedicated dosing tools.
References
Worked calculation
The values below come from this tool's own example placeholders and are computed server-side with the formula shown on this page, so the arithmetic can be checked quickly. It demonstrates how to substitute values only — it is not clinical advice and not a real case.
| Drug | Digoxin |
|---|
→Target range0.5–2.0 ng/mL (HF 0.5–0.9)
- Sampling：≥ 6–8 h after last dose
- Toxicity：> 2.0 toxic; hypokalaemia/hypomagnesaemia/renal impairment sensitise
| Drug | Voriconazole |
|---|
→Target rangeTrough 1–5.5 mg/L
- Sampling：Steady-state trough on day 5
- Toxicity：Hepatotoxicity, neuro/visual, QT
Frequently asked questions
- What is Therapeutic Drug Monitoring (TDM) Targets?
- Quick reference to therapeutic ranges, sampling timing and toxicity cues for commonly monitored drugs — digoxin, antiepileptics, lithium, vancomycin, aminoglycosides and more. Browser-side.
- How is Therapeutic Drug Monitoring (TDM) Targets calculated? What is the core formula?
- Examples: digoxin 0.5–2.0 ng/mL (HF 0.5–0.9); phenytoin total 10–20 µg/mL; lithium 0.6–1.0 mmol/L; vancomycin AUC/MIC 400–600.
- When is Therapeutic Drug Monitoring (TDM) Targets used?
- Look up the target range and when to sample (trough/peak/steady state). Interpret levels with clinical efficacy and toxicity.
- What are the key clinical points for Therapeutic Drug Monitoring (TDM) Targets?
- Units and assays vary between laboratories. Wrong sampling timing (before steady state, not a true trough/peak) causes misinterpretation. A subtherapeutic level with good clinical response need not be changed. For vancomycin and aminoglycosides see the dedicated dosing tools.
- What are the limits and cautions when using Therapeutic Drug Monitoring (TDM) Targets?
- For licensed clinicians and clinical researchers. Interpret results with history, investigations and local protocols; not a diagnosis or prescription, and not a substitute for multidisciplinary decision-making or local guidelines.
- How is Therapeutic Drug Monitoring (TDM) Targets calculated in practice? Can you show a worked example?
- Inputs: Drug Digoxin → Result: Target range 0.5–2.0 ng/mL (HF 0.5–0.9)（Sampling: ≥ 6–8 h after last dose, Toxicity: > 2.0 toxic; hypokalaemia/hypomagnesaemia/renal impairment sensitise） Inputs: Drug Voriconazole → Result: Target range Trough 1–5.5 mg/L（Sampling: Steady-state trough on day 5, Toxicity: Hepatotoxicity, neuro/visual, QT）