🩸 HOMA-IR (Insulin Resistance)
Estimate insulin resistance from fasting glucose and insulin with HOMA-IR.
Clinical takeaway
Cut-offs vary by population and assay (~2.5–2.9).
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When to use
Assess insulin resistance in metabolic and endocrine work-ups.
How it works
HOMA-IR = (fasting glucose mg/dL × fasting insulin µU/mL) / 405.
Key points
- Cut-offs vary by population and assay (~2.5–2.9).
- Requires true fasting samples.
- Use trends and local references, not a universal threshold.
References
Decision support for licensed clinicians only; not a substitute for clinical judgement, diagnosis or local protocols.
Worked calculation
The values below come from this tool's own example placeholders and are computed server-side with the formula shown on this page, so the arithmetic can be checked quickly. It demonstrates how to substitute values only — it is not clinical advice and not a real case.
| Fasting glucose | 100 mg/dL |
|---|---|
| Fasting insulin | 10 µU/mL |
→HOMA-IR2.47
- Formula：(glucose mg/dL × insulin µU/mL) / 405
- Interpretation：Average.
Frequently asked questions
- What is HOMA-IR (Insulin Resistance)?
- Estimate insulin resistance from fasting glucose and insulin with HOMA-IR.
- How is HOMA-IR (Insulin Resistance) calculated? What is the core formula?
- HOMA-IR = (fasting glucose mg/dL × fasting insulin µU/mL) / 405.
- When is HOMA-IR (Insulin Resistance) used?
- Assess insulin resistance in metabolic and endocrine work-ups.
- What are the key clinical points for HOMA-IR (Insulin Resistance)?
- Cut-offs vary by population and assay (~2.5–2.9). Requires true fasting samples. Use trends and local references, not a universal threshold.
- What are the limits and cautions when using HOMA-IR (Insulin Resistance)?
- For licensed clinicians and clinical researchers. Interpret results with history, investigations and local protocols; not a diagnosis or prescription, and not a substitute for multidisciplinary decision-making or local guidelines.
- How is HOMA-IR (Insulin Resistance) calculated in practice? Can you show a worked example?
- Inputs: Fasting glucose 100 mg/dL, Fasting insulin 10 µU/mL → Result: HOMA-IR 2.47（Formula: (glucose mg/dL × insulin µU/mL) / 405, Interpretation: Average.）