💉 Unfractionated Heparin (UFH) Weight-Based Dosing
Weight-based unfractionated heparin (UFH) IV loading dose and initial maintenance rate by the Raschke nomogram, for VTE or ACS. aPTT/anti-Xa guided. Browser-side.
Clinical takeaway
Recheck aPTT 6 h after starting and after each rate change.
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When to use
Choose an initial weight-based UFH regimen; subsequent rates are titrated by aPTT or anti-Xa and your institutional nomogram.
How it works
VTE: 80 U/kg bolus + 18 U/kg/h. ACS: 60 U/kg (max 4000) bolus + 12 U/kg/h (max 1000). Target aPTT 1.5–2.5× control or anti-Xa 0.3–0.7 IU/mL.
Key points
- Recheck aPTT 6 h after starting and after each rate change.
- Monitor platelets for heparin-induced thrombocytopenia (HIT).
- Watch for bleeding and impaired renal function.
- Always titrate by your institution's nomogram.
References
Decision support for licensed clinicians only; not a substitute for clinical judgement, diagnosis or local protocols.
Frequently asked questions
- What is Unfractionated Heparin (UFH) Weight-Based Dosing?
- Weight-based unfractionated heparin (UFH) IV loading dose and initial maintenance rate by the Raschke nomogram, for VTE or ACS. aPTT/anti-Xa guided. Browser-side.
- How is Unfractionated Heparin (UFH) Weight-Based Dosing calculated? What is the core formula?
- VTE: 80 U/kg bolus + 18 U/kg/h. ACS: 60 U/kg (max 4000) bolus + 12 U/kg/h (max 1000). Target aPTT 1.5–2.5× control or anti-Xa 0.3–0.7 IU/mL.
- When is Unfractionated Heparin (UFH) Weight-Based Dosing used?
- Choose an initial weight-based UFH regimen; subsequent rates are titrated by aPTT or anti-Xa and your institutional nomogram.
- What are the key clinical points for Unfractionated Heparin (UFH) Weight-Based Dosing?
- Recheck aPTT 6 h after starting and after each rate change. Monitor platelets for heparin-induced thrombocytopenia (HIT). Watch for bleeding and impaired renal function. Always titrate by your institution's nomogram.
- What are the limits and cautions when using Unfractionated Heparin (UFH) Weight-Based Dosing?
- For licensed clinicians and clinical researchers. Interpret results with history, investigations and local protocols; not a diagnosis or prescription, and not a substitute for multidisciplinary decision-making or local guidelines.