💊 Acetaminophen (Paracetamol) Dose & Toxicity Threshold
Check acetaminophen (paracetamol) daily and single-dose limits, and assess whether an acute ingestion reaches the toxic threshold or warrants N-acetylcysteine. Instant, browser-side.
Clinical takeaway
Lower the ceiling with chronic alcohol use, liver disease, malnutrition/fasting or isoniazid.
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When to use
Verify therapeutic dosing and triage an acute overdose by mg/kg ingested. Use the Rumack-Matthew nomogram on a timed 4-hour level for the definitive NAC decision.
How it works
Adult (≥ 50 kg): single ≤ 1 g, daily ≤ 4 g. Child (< 50 kg): ≤ 15 mg/kg/dose, ≤ 75 mg/kg/day. Acute toxic threshold ≥ 150 mg/kg.
Key points
- Lower the ceiling with chronic alcohol use, liver disease, malnutrition/fasting or isoniazid.
- Single acute ingestion ≥ 150 mg/kg (adult ≈ 7.5–10 g) risks hepatotoxicity.
- NAC within 8 hours is nearly fully hepatoprotective.
- Watch for hidden acetaminophen in combination products and for extended-release kinetics.
References
Decision support for licensed clinicians only; not a substitute for clinical judgement, diagnosis or local protocols.
Frequently asked questions
- What is Acetaminophen (Paracetamol) Dose & Toxicity Threshold?
- Check acetaminophen (paracetamol) daily and single-dose limits, and assess whether an acute ingestion reaches the toxic threshold or warrants N-acetylcysteine. Instant, browser-side.
- How is Acetaminophen (Paracetamol) Dose & Toxicity Threshold calculated? What is the core formula?
- Adult (≥ 50 kg): single ≤ 1 g, daily ≤ 4 g. Child (< 50 kg): ≤ 15 mg/kg/dose, ≤ 75 mg/kg/day. Acute toxic threshold ≥ 150 mg/kg.
- When is Acetaminophen (Paracetamol) Dose & Toxicity Threshold used?
- Verify therapeutic dosing and triage an acute overdose by mg/kg ingested. Use the Rumack-Matthew nomogram on a timed 4-hour level for the definitive NAC decision.
- What are the key clinical points for Acetaminophen (Paracetamol) Dose & Toxicity Threshold?
- Lower the ceiling with chronic alcohol use, liver disease, malnutrition/fasting or isoniazid. Single acute ingestion ≥ 150 mg/kg (adult ≈ 7.5–10 g) risks hepatotoxicity. NAC within 8 hours is nearly fully hepatoprotective. Watch for hidden acetaminophen in combination products and for extended-release kinetics.
- What are the limits and cautions when using Acetaminophen (Paracetamol) Dose & Toxicity Threshold?
- For licensed clinicians and clinical researchers. Interpret results with history, investigations and local protocols; not a diagnosis or prescription, and not a substitute for multidisciplinary decision-making or local guidelines.