Vasoactive Agents & MAP Target in Septic Shock — free guideline decision tool
Vasoactive-agent and MAP-target framework for septic shock, following the Surviving Sepsis Campaign escalation sequence.
Open guideline tool →Guideline-based
Implements the decision logic from published clinical guidelines.
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No installation. Enter the patient's values and get a guideline recommendation instantly.
Data stays local
Nothing is uploaded. Results are for licensed clinicians only.
Worked calculation
The values below come from this tool's own example placeholders and are computed server-side with the formula shown on this page, so the arithmetic can be checked quickly. It demonstrates how to substitute values only — it is not clinical advice and not a real case.
| Current MAP (after adequate fluid resuscitation) | 60 mmHg |
|---|---|
| Current vasoactive agent | None |
| Cardiac dysfunction with persistent hypoperfusion | No |
→MAP60 mmHg (not met)
- MAP target：Initial target MAP ≥ 65 mmHg (not superior to higher targets; permissive hypotension 60–65 acceptable in the elderly). Current 60 mmHg (not met)
- Next step：Norepinephrine first-line, titrate to MAP ≥ 65 mmHg
- Drug tips：Norepinephrine is preferred with tachyarrhythmia; epinephrine may be preferred with bradyarrhythmia. Once the target is met, use the lowest effective dose and avoid prolonged high-dose norepinephrine
Common questions
What is Vasoactive Agents & MAP Target in Septic Shock?
Vasoactive-agent and MAP-target framework for septic shock, following the Surviving Sepsis Campaign escalation sequence.
How is Vasoactive Agents & MAP Target in Septic Shock calculated? What is the core formula?
Initial MAP target ≥ 65 mmHg; norepinephrine first-line → add vasopressin 0.03 U/min → add epinephrine; add dobutamine (or switch to epinephrine) for cardiac dysfunction with persistent hypoperfusion; add hydrocortisone 200 mg/d for ongoing vasopressor need (≥ 0.25 µg/kg/min ≥ 4 h).
When is Vasoactive Agents & MAP Target in Septic Shock used?
Use after adequate fluid resuscitation to set the MAP target and choose the next vasopressor/inotrope/steroid step.
What are the key clinical points for Vasoactive Agents & MAP Target in Septic Shock?
Adding vasopressin is preferred over escalating norepinephrine indefinitely, sparing catecholamine dose (original synthesis · not guideline verbatim). A MAP target above 65 mmHg has not shown benefit and increases arrhythmia risk; permissive 60–65 is acceptable in the elderly. Inotropes are added to, not substituted for, vasopressors when cardiac dysfunction coexists with hypoperfusion.
What are the limits and cautions when using Vasoactive Agents & MAP Target in Septic Shock?
For licensed clinicians and clinical researchers. Interpret results with history, investigations and local protocols; not a diagnosis or prescription, and not a substitute for multidisciplinary decision-making or local guidelines.
How is Vasoactive Agents & MAP Target in Septic Shock calculated in practice? Can you show a worked example?
Inputs: Current MAP (after adequate fluid resuscitation) 60 mmHg, Current vasoactive agent None, Cardiac dysfunction with persistent hypoperfusion No → Result: MAP 60 mmHg (not met)（MAP target: Initial target MAP ≥ 65 mmHg (not superior to higher targets; permissive hypotension 60–65 acceptable in the elderly). Current 60 mmHg (not met), Next step: Norepinephrine first-line, titrate to MAP ≥ 65 mmHg, Drug tips: Norepinephrine is preferred with tachyarrhythmia; epinephrine may be preferred with bradyarrhythmia. Once the target is met, use the lowest effective dose and avoid prolonged high-dose norepinephrine）
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Vasoactive-agent and MAP-target framework for septic shock, following the Surviving Sepsis Campaign escalation sequence.
Open guideline tool →For licensed clinicians. Not a substitute for clinical judgement.
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