Risk of Ovarian Malignancy Algorithm (ROMA Index) — free guideline decision tool
Combine HE4, CA-125 and menopausal status to compute ROMA% and triage an adnexal mass into high or low risk of epithelial ovarian cancer. Instant, browser-side.
Open guideline tool →Guideline-based
Implements the decision logic from published clinical guidelines.
Runs in your browser
No installation. Enter the patient's values and get a guideline recommendation instantly.
Data stays local
Nothing is uploaded. Results are for licensed clinicians only.
Common questions
What does Risk of Ovarian Malignancy Algorithm (ROMA Index) do?
Pre-operative benign/malignant triage of an adnexal mass (not population screening), complementary to RMI and O-RADS.
How is the result calculated?
PI(pre) = −12.0 + 2.38·ln(HE4) + 0.0626·ln(CA125); PI(post) = −8.09 + 1.04·ln(HE4) + 0.732·ln(CA125); ROMA = e^PI/(1 + e^PI) × 100. High-risk cut-off varies by platform.
Is this a substitute for clinical judgement?
No. All results are decision-support only, for licensed clinicians. They must be individualized to the whole patient and the latest guideline version.
Run Risk of Ovarian Malignancy Algorithm (ROMA Index) now
Combine HE4, CA-125 and menopausal status to compute ROMA% and triage an adnexal mass into high or low risk of epithelial ovarian cancer. Instant, browser-side.
Open guideline tool →For licensed clinicians. Not a substitute for clinical judgement.