Opioid Overdose Reversal (Naloxone) — free guideline decision tool
This tool gives the naloxone dosing strategy for opioid overdose by setting and dependence, emphasizing ventilatory support and observation for recurrence.
Open guideline tool →Guideline-based
Implements the decision logic from published clinical guidelines.
Runs in your browser
No installation. Enter the patient's values and get a guideline recommendation instantly.
Data stays local
Nothing is uploaded. Results are for licensed clinicians only.
Common questions
What does Opioid Overdose Reversal (Naloxone) do?
Use to start airway/ventilation first, then dose naloxone appropriately, titrating low in dependent patients and observing for re-narcotization.
How is the result calculated?
Airway/ventilation first. Out-of-hospital 0.4 mg IM or 4 mg intranasal. In-hospital non-dependent 0.4 mg IV titrated; dependent 0.04–0.1 mg IV to avoid withdrawal; up to 10 mg. Observe ≥ 2–4 h; infusion for long-acting/large overdoses.
Is this a substitute for clinical judgement?
No. All results are decision-support only, for licensed clinicians. They must be individualized to the whole patient and the latest guideline version.
Run Opioid Overdose Reversal (Naloxone) now
This tool gives the naloxone dosing strategy for opioid overdose by setting and dependence, emphasizing ventilatory support and observation for recurrence.
Open guideline tool →For licensed clinicians. Not a substitute for clinical judgement.