Maddrey Discriminant Function (Alcoholic Hepatitis) — free guideline decision tool
Grade alcoholic hepatitis severity with the Maddrey discriminant function (DF).
Open guideline tool →Guideline-based
Implements the decision logic from published clinical guidelines.
Runs in your browser
No installation. Enter the patient's values and get a guideline recommendation instantly.
Data stays local
Nothing is uploaded. Results are for licensed clinicians only.
Worked calculation
The values below come from this tool's own example placeholders and are computed server-side with the formula shown on this page, so the arithmetic can be checked quickly. It demonstrates how to substitute values only — it is not clinical advice and not a real case.
| Patient prothrombin time | 20 s |
|---|---|
| Control PT | 12 s |
| Total bilirubin | 8 mg/dL |
→Maddrey DF44.8
- Interpretation：≥ 32: severe alcoholic hepatitis — consider corticosteroids (if no contraindication) and assess MELD/Lille.
- Formula：4.6 × (PT − control PT) + bilirubin (mg/dL)
Common questions
What is Maddrey Discriminant Function (Alcoholic Hepatitis)?
Grade alcoholic hepatitis severity with the Maddrey discriminant function (DF).
How is Maddrey Discriminant Function (Alcoholic Hepatitis) calculated? What is the core formula?
DF = 4.6 × (patient PT − control PT) + total bilirubin (mg/dL). DF ≥ 32 = severe.
When is Maddrey Discriminant Function (Alcoholic Hepatitis) used?
Decide on corticosteroid therapy in alcoholic hepatitis.
What are the key clinical points for Maddrey Discriminant Function (Alcoholic Hepatitis)?
DF ≥ 32 indicates severe disease with high short-term mortality. The classic threshold for considering corticosteroids. Reassess steroid response with the Lille score; MELD also used.
What are the limits and cautions when using Maddrey Discriminant Function (Alcoholic Hepatitis)?
For licensed clinicians and clinical researchers. Interpret results with history, investigations and local protocols; not a diagnosis or prescription, and not a substitute for multidisciplinary decision-making or local guidelines.
How is Maddrey Discriminant Function (Alcoholic Hepatitis) calculated in practice? Can you show a worked example?
Inputs: Patient prothrombin time 20 s, Control PT 12 s, Total bilirubin 8 mg/dL → Result: Maddrey DF 44.8（Interpretation: ≥ 32: severe alcoholic hepatitis — consider corticosteroids (if no contraindication) and assess MELD/Lille., Formula: 4.6 × (PT − control PT) + bilirubin (mg/dL)）
Run Maddrey Discriminant Function (Alcoholic Hepatitis) now
Grade alcoholic hepatitis severity with the Maddrey discriminant function (DF).
Open guideline tool →For licensed clinicians. Not a substitute for clinical judgement.
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