GTN WHO/FIGO Prognostic Score — free guideline decision tool
Stratify gestational trophoblastic neoplasia with the WHO/FIGO prognostic score.
Open guideline tool →Guideline-based
Implements the decision logic from published clinical guidelines.
Runs in your browser
No installation. Enter the patient's values and get a guideline recommendation instantly.
Data stays local
Nothing is uploaded. Results are for licensed clinicians only.
Worked calculation
The values below come from this tool's own example placeholders and are computed server-side with the formula shown on this page, so the arithmetic can be checked quickly. It demonstrates how to substitute values only — it is not clinical advice and not a real case.
| Age | < 40 y (0) |
|---|---|
| Antecedent pregnancy | Hydatidiform mole (0) |
| Interval from antecedent pregnancy (months) | < 4 (0) |
| Pretreatment serum hCG (IU/L) | < 10³ (0) |
| Largest tumor (incl. uterus) | < 3 cm (0) |
| Site of metastases | Lung (0) |
| Number of metastases | 0 (0) |
| Prior failed chemotherapy | None (0) |
→FIGO score0
- Prognostic score：0 → Low risk (≤ 6)
- Treatment：Low-risk GTN: single-agent chemotherapy (methotrexate or actinomycin D); switch agent or escalate if resistant
- Note：Expressed with the FIGO anatomic stage (e.g. III:5); does not apply to PSTT or epithelioid trophoblastic tumor
| Age | ≥ 40 y (1) |
|---|---|
| Antecedent pregnancy | Term pregnancy (2) |
| Interval from antecedent pregnancy (months) | > 12 (4) |
| Pretreatment serum hCG (IU/L) | > 10⁵ (4) |
| Largest tumor (incl. uterus) | ≥ 5 cm (2) |
| Site of metastases | Liver/brain (4) |
| Number of metastases | > 8 (4) |
| Prior failed chemotherapy | ≥ 2 drugs (4) |
→FIGO score25
- Prognostic score：25 → High risk (≥ 7)
- Treatment：High-risk GTN: combination chemotherapy (e.g. EMA-CO), salvage and multidisciplinary care as needed; individualized treatment for brain/liver metastases
- Note：Expressed with the FIGO anatomic stage (e.g. III:5); does not apply to PSTT or epithelioid trophoblastic tumor
Common questions
What is GTN WHO/FIGO Prognostic Score?
Stratify gestational trophoblastic neoplasia with the WHO/FIGO prognostic score.
How is GTN WHO/FIGO Prognostic Score calculated? What is the core formula?
Sum 8 factors (age, antecedent pregnancy, interval, hCG, tumor size, metastatic site, number of metastases, prior failed chemo). ≤ 6 low risk, ≥ 7 high risk.
When is GTN WHO/FIGO Prognostic Score used?
Decide between single-agent and combination chemotherapy in GTN.
What are the key clinical points for GTN WHO/FIGO Prognostic Score?
Low risk → single-agent (methotrexate/actinomycin D). High risk → combination chemotherapy (e.g. EMA-CO). Expressed with the FIGO anatomic stage; not for PSTT/ETT.
What are the limits and cautions when using GTN WHO/FIGO Prognostic Score?
For licensed clinicians and clinical researchers. Interpret results with history, investigations and local protocols; not a diagnosis or prescription, and not a substitute for multidisciplinary decision-making or local guidelines.
How is GTN WHO/FIGO Prognostic Score calculated in practice? Can you show a worked example?
Inputs: Age < 40 y (0), Antecedent pregnancy Hydatidiform mole (0), Interval from antecedent pregnancy (months) < 4 (0), Pretreatment serum hCG (IU/L) < 10³ (0), Largest tumor (incl. uterus) < 3 cm (0), Site of metastases Lung (0), Number of metastases 0 (0), Prior failed chemotherapy None (0) → Result: FIGO score 0（Prognostic score: 0 → Low risk (≤ 6), Treatment: Low-risk GTN: single-agent chemotherapy (methotrexate or actinomycin D); switch agent or escalate if resistant, Note: Expressed with the FIGO anatomic stage (e.g. III:5); does not apply to PSTT or epithelioid trophoblastic tumor） Inputs: Age ≥ 40 y (1), Antecedent pregnancy Term pregnancy (2), Interval from antecedent pregnancy (months) > 12 (4), Pretreatment serum hCG (IU/L) > 10⁵ (4), Largest tumor (incl. uterus) ≥ 5 cm (2), Site of metastases Liver/brain (4), Number of metastases > 8 (4), Prior failed chemotherapy ≥ 2 drugs (4) → Result: FIGO score 25（Prognostic score: 25 → High risk (≥ 7), Treatment: High-risk GTN: combination chemotherapy (e.g. EMA-CO), salvage and multidisciplinary care as needed; individualized treatment for brain/liver metastases, Note: Expressed with the FIGO anatomic stage (e.g. III:5); does not apply to PSTT or epithelioid trophoblastic tumor）
Run GTN WHO/FIGO Prognostic Score now
Stratify gestational trophoblastic neoplasia with the WHO/FIGO prognostic score.
Open guideline tool →For licensed clinicians. Not a substitute for clinical judgement.
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