Anticoagulant-Related Major Bleeding Reversal — free guideline decision tool
This tool gives the specific reversal agent and general hemostatic support for anticoagulant-related major bleeding, by anticoagulant class.
Open guideline tool →Guideline-based
Implements the decision logic from published clinical guidelines.
Runs in your browser
No installation. Enter the patient's values and get a guideline recommendation instantly.
Data stays local
Nothing is uploaded. Results are for licensed clinicians only.
Common questions
What does Anticoagulant-Related Major Bleeding Reversal do?
Use in major or life-threatening bleeding to pair the correct antidote with the drug class while applying general measures and planning restart.
How is the result calculated?
VKA → vitamin K + 4F-PCC (or FFP). Dabigatran → idarucizumab (or PCC/dialysis). Xa inhibitor → andexanet alfa (or 4F-PCC). Heparin → protamine (1 mg per ~100 U).
Is this a substitute for clinical judgement?
No. All results are decision-support only, for licensed clinicians. They must be individualized to the whole patient and the latest guideline version.
Run Anticoagulant-Related Major Bleeding Reversal now
This tool gives the specific reversal agent and general hemostatic support for anticoagulant-related major bleeding, by anticoagulant class.
Open guideline tool →For licensed clinicians. Not a substitute for clinical judgement.