Case challenge · Imaging / Fetal medicine / Prenatal diagnosis · teaching

Holoprosencephaly (HPE) Fetal MRI · case challenge

Given a case, work through the care pathway step by step; the tool checks each choice and scores you. Decisions and basis are taken from this site's reviewed care pathways.

← View the full flowchartBased on DeMyer classification

Case #1Imaging / Fetal medicine / Prenatal diagnosis

📋 Case data

Degree of forebrain cleavage (DeMyer) + faceAlobar (monoventricle + dorsal cyst, fused thalami, no falx/interhemispheric fissure, severe facial anomaly)

Data is taken from this pathway's reviewed node text. Work through the pathway step by step.

Step 1 / 1 · Degree of forebrain cleavage (DeMyer) + face

Degree of forebrain cleavage (DeMyer classification) + face?

💡 HPE = a disorder of forebrain cleavage. Common feature = absent cavum septi pellucidi. The face predicts the brain (facial anomaly is a clue). Severe forms detectable early on ultrasound, fetal MRI second-line to confirm the type + face + associated anomalies; chromosomes (trisomy 13 common).

For teaching. Decisions and their basis are taken from this site's reviewed care pathways; for licensed clinicians/trainees, this does not replace clinical judgment or local protocols.